Some AI tools don’t understand biology yet

Biology is an area of science where AI and machine-learning approaches have seen some spectacular successes, such as designing enzymes to digest plastics and proteins to block snake venom. But in an era of seemingly endless AI hype, it might be easy to think that we could just set AI loose on the mounds of data we've already generated and end up with a good understanding of most areas of biology, allowing us to skip a lot of messy experiments and the unpleasantness of research on animals.

But biology involves a whole lot more than just protein structures. And it's extremely premature to suggest that AI can be equally effective at handling all aspects of biology. So we were intrigued to see a study comparing a set of AI software packages designed to predict how active genes will be in cells exposed to different conditions. As it turns out, the AI systems couldn't manage to do any better than a deliberately simplified method of predicting.

The results serve as a useful caution that biology is incredibly complex, and developing AI systems that work for one aspect of it is not an indication that they can work for biology generally.

AI and gene activity

The study was conducted by a trio of researchers based in Heidelberg: Constantin Ahlmann-Eltze, Wolfgang Huber, and Simon Anders. They note that a handful of additional studies have been released while their work was on a pre-print server, all of them coming to roughly the same conclusions. But these authors' approach is pretty easy to understand, so we'll use it as an example.